IndraLab

Statements

WNT11 binds ROR2. 19 / 19
| 3 16
sparser
"Ror2 physically interacts with Wnt11."
24928507
reach
"Wnt5a and Wnt11 binding to FZD and/or RoR2 also can lead to intracellular Ca 2+ release, which activates Ca 2+ / calmodulin dependent kinase II (CaMKII) and protein kinase C (PKC) 32."
29453334
sparser
"In zebrafish, Wnt11 , but not Wnt5a , is expressed highly at gastrula-stage embryos and Wnt11-Ror2 signaling is implicated in regulating CE movements during gastrulation ( xref )."
35493090
reach
"Binding of Wnt4, Wnt5a or Wnt11 to Fz and non canonical Fz co-receptors such as RYK, and ROR2, activates the Rho and Rac GTPases, leading to cytoskeletal modifications."
28522145
sparser
"Using co-immunoprecipitations, we verified the interaction of ROR2 with the identified ligand, WNT11."
34911552
sparser
"Co-immunoprecipitation confirmed that WNT11 indeed interacts with the cysteine-rich domain of ROR2 and triggers its invasion-promoting signaling via RHO/ROCK."
34911552
sparser
"Wnt5a- or Wnt11-Ror2 signaling can mediate IL-1β-induced neuronal cell death, suggesting that Ror2-mediated signaling might promote the pathology of the neurodegenerative diseases."
35493090
sparser
"Wnt11-Ror2 signaling plays a critical role in regulating MP proliferation, differentiation, and senescence."
39468010
sparser
"It was further confirmed that Wnt11 could associate with Ror2 via its extracellular CRD (Fig. xref )."
39468010
sparser
"Therefore, we hypothesized that Wnt11-Ror2 signaling, activated by autocrine or paracrine machinery, can inhibit senescence of MPs, while promoting their proliferation and adipogenic differentiation."
39468010
sparser
"These results indicated that Wnt11-Ror2 signaling is required to regulate MP proliferation, adipogenic differentiation, and senescence."
39468010
sparser
"Wnt11-Ror2 signaling suppresses MP senescence by inhibiting nuclear membrane blebbing."
39468010
sparser
"Wnt11-Ror2 signaling is involved in cell migration and actin remodeling [ xref , xref ]."
39468010
sparser
"Based on these findings, we reasoned that Wnt11-Ror2 signaling suppresses cGas-mediated cellular senescence by inhibiting nuclear blebbing induced by perinuclear actin fibers."
39468010
sparser
"On the other hand, Wnt5a failed to affect binding of Wnt11 to Ror2, and Wnt11 inhibited binding of Wnt5a to Ror2 (Supplementary Fig. xref )."
39468010
sparser
"Wnt11-Ror2 signaling promotes MP proliferation and adipogenic differentiation and inhibits cellular senescence by regulating stress fiber-induced nuclear blebbing, associated with cGas-STING pathway activation."
39468010
reach
"Ror2 physically interacts with Wnt11."
24928507
sparser
"Wnt11 and Wnt5b bind to the extracellular CRD of Ror2 expressed on MPs to activate Wnt11-Ror2 and Wnt5b-Ror2 signaling, respectively."
39468010
sparser
"Although Wnt5b and Wnt11 could bind cooperatively to Ror2, Wnt5a failed to affect the binding of Wnt11 to Ror2."
39468010