IndraLab

Statements

BRCC3 activates HYCC1. 3 / 3
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"We found that BRCC36 overexpression upregulated the expression of GPX4 and HMGCR, while decreasing the levels of 4‐HNE (4‐hydroxy‐2‐noneal), a biomarker of ferroptosis (Figure 6I,J), indicating BRCC36 inhibits ferroptosis in HCC."
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"To further examine whether BRCC36 overexpression promotes HCC cell growth in vivo, an SMMC7721 xenograft model was established."
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"Moreover, thiolutin, an inhibitor of BRCC36, slowed the progression of HCC, suggesting that BRCC36 could be as a therapeutic target for HCC."
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