IndraLab

Statements

USP7 activates USP22. 5 / 5
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"In the study, we found that USP7 inhibition by three inhibitors: HBX4418 [45], P5091 [41], and FT671 [12] dramatically upregulates USP22 in cancer cells through transcriptional mechanisms, and given the critical role of USP22 in carcinogenesis and anticancer response, we propose that the upregulated USP22 may represent a critical side-effects of USP7 inhibition.We further examined the expression and activation of downstream signaling of USP22 pathway by USP7 inhibition and found that this feedback upregulation has a significant impact on USP22 pathway and USP22-related oncogenes."
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"In the study, we found that targeting USP7 via either siRNA-mediated knockdown or pharmaceutical inhibitors dramatically upregulates USP22 in cancer cells."
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"We hypothesized that USP7-induced USP22 may be responsible for the insensitivity."
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"Targeting USP7 significantly upregulated USP22 in cancer cells."
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"We found that the USP7-specific inhibitor FT671 [12] dramatically upregulates USP22 protein in a dose-dependent manner, even at a very low concentration that barely affects cellular proliferation in lung cancer cell line A549 (Fig. 1A)."
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