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USP15 inhibits CTNNB1. 2 / 2

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"USP4 negatively regulates Wnt signaling by interacting with Nemolike kinase [XREF_BIBR] and USP15 promotes beta-catenin degradation through the stabilization of adenomatous polyposis coli (APC), a negative regulator of Wnt mediated transcription [XREF_BIBR]."

25972356

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reach

"USP15 in turn prevents the basal turnover of beta-catenin by inhibiting its ubiquitin dependent proteasomal degradation, thereby enhancing WNT signaling."

26884171

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IndraLab

Statements

USP15 inhibits CTNNB1. 2 / 2

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