IndraLab

Statements

USP1 inhibits DNA Damage. 5 / 5
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"Inhibition of USP1 has allowed us to uncouple DNA damage or S phase arrest from the induction of FANCD2 monoubiquitination."
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"We asked whether USP1 inhibition in sensitive cells induces DNA damage."
36228090
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"Taken together, our results suggest USP1 inhibition elicits DNA damage and replication stress, thereby causing cell-cycle arrest followed by death in BRCA1/2 mutant cells."
36228090
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"Although we show that TNG348 induces PARylation, implying that the DNA damage induced by USP1 inhibition requires PARP activity for repair, the mechanism through which USP1 inhibition by TNG348 synergizes with PARPi is likely multifactorial."
39886906
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"Because USP1 is reported to target PCNA and FANCD2 during DNA repair (Nijman et al., 2005; Huang et al., 2006), we also checked if USP1 knockdown produced DNA damage."
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