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3',5'-cyclic AMP binds KCNH2. 2 / 3

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"CAMP interacts with the HERG protein by binding to the cAMP-binding domain of HERG protein and subsequently impacts HERG in GAC (43)."

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"Elevation of cAMP can modulate HERG K+ channels both by direct binding and indirect regulation through protein kinase A. To assess the physiological significance of cAMP binding to HERG, we introduced mutations to disrupt the cyclic nucleotide binding domain."

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IndraLab

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3',5'-cyclic AMP binds KCNH2. 2 / 3

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