IndraLab

Statements

RHEB binds RPTOR and MTOR. 4 / 4
| 1 3
sparser
"In addition to directly phosphorylating mTOR, AKT also phosphorylates TSC2, which results in a Rheb-mediated interaction between mTOR and Raptor (regulatory associated protein of mTOR) to create mTOR complex 1 (mTORC1)."
23676467
sparser
"Whether TSC1/2 and/or Rheb binds to the mTOR complex containing raptor and modulates the signaling function and kinase activity of mTOR remains an important but unanswered question."
14684181
sparser
"Recombinant SIRT6 alleviated the decrease in AMPKα and increase in mTORC1 (complex of mTOR, Raptor, and Rheb) caused by overnutrition."
34923569
reach
"This suggests that the drop of p-Akt/Akt ratio caused the observed up regulation of MuRF1 and MAFbx in the EDL muscle.p-AKT also promotes protein synthesis through the upregulation of the mTOR-raptor-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27102410