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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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RHEB binds RPTOR and MTOR. 3 / 3

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"Whether TSC1/2 and/or Rheb binds to the mTOR complex containing raptor and modulates the signaling function and kinase activity of mTOR remains an important but unanswered question."

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"In addition to directly phosphorylating mTOR, AKT also phosphorylates TSC2, which results in a Rheb-mediated interaction between mTOR and Raptor (regulatory associated protein of mTOR) to create mTOR complex 1 (mTORC1)."

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"Recombinant SIRT6 alleviated the decrease in AMPKα and increase in mTORC1 (complex of mTOR, Raptor, and Rheb) caused by overnutrition."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

RHEB binds RPTOR and MTOR. 3 / 3

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