IndraLab

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KCNH2 activates LQTS1. 4 / 4
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"Therefore, the effects of dextromethorphan on the dysfunction of other affected organs remain to be investigated.In conclusion, although the role of SIGMAR1 has emerged in various diseases including neurological disorders and cancer and more recently cardiovascular diseases and COVID-19 , our findings demonstrate that SIGMAR1 could be a therapeutic target for TS and potentially LQTS1 and LQTS2 caused by the G269S mutation in K 7.1 channel and the A561V mutation in hERG channel, respectively."
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"Mutations in KCNQ1 and HERG cause the congenital LQTS1 XREF_BIBR and LQTS2, XREF_BIBR respectively."
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"However, most pathogenic variants are still identified in the three first described genes : KCNQ1, KCNH2, and SCN5A [XREF_BIBR, XREF_BIBR], causing LQTS1, LQTS2, and LQTS3, respectively."
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"Our results demonstrated that SIGMAR1 activation could be beneficial for not only TS but also LQTS1 and LQTS2, which are caused by the G269S mutation in K 7.1 channel and the A561V mutation in hERG channel, respectively."
36051854