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BAP1 binds FOXK2. 44 / 44
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"In addition, the N-terminal portions (amino acids 8–190) including FHA domain are required for the interaction of FOXK2 with BAP1 [ 48 ]."
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19815555
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25609649
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"Sites within this central region have been identified as important for binding non ASXL complex components; for example, the HCF binding motif and the phosphorylated threonine residue that mediates BAP1 's interaction with FOXK2 have been mapped to this region [XREF_BIBR, XREF_BIBR]."
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"BAP1 also associates with transcription factors, including FOXK1, FOXK2, and Yin Yang1 (YY1), which ensure the recruitment of this DUB to chromatin (133, 142)."
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"Previous study indicated that FOXK2 interacted with deubiquitinase BAP1 and recruited BAP1 to DNA which promoted local histone deubiquitation and caused changes in target genes [12,13] ."
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"FOXK2 binds to the BAP1 containing PR and DUB complex."
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"Although BAP1 interacts with a transcriptional regulator, HCF-1, and transcription factors FoxK1 and FoxK2, how BAP1 controls gene expression remains unclear."
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"The BAP1-FOXK2 interaction is abrogated with a mutant version of FOXK2 with impaired phosphopeptide binding activity, suggesting a dependency on the FHA domain of FOXK2 [ xref ]."
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"In lung cancer cells, BAP1 directly binds to FOXK2 via its Thr(P)-493 and recruits HCF-1 to repress the expression of FOXK2 target genes [ 48 ]."
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"To provide insights into complex formation between FOXK2 and BAP1, we first mapped the region of FOXK2 responsible for binding to BAP1."
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"It therefore appears likely that the R58A mutation does more than affect phospho dependent interactions but underscores the importance of this domain in mediating interactions between FOXK2 and BAP1."
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"Previous study indicated that FOXK2 interacted with deubiquitinase BAP1 and recruited BAP1 to DNA which promoted local histone deubiquitation and caused changes in target genes [12,13] ."
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"Functional interactions between FOXK2 and BAP1 in target locus regulation."
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"The amino acid region 8–190 primarily mediates the interaction between FOXK2 and BAP1 ( xref ) ( xref )."
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"First, we demonstrated that endogenous FOXK2 and BAP1 interact in reciprocal co-IP experiments (Figure xref and xref )."
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"Binding of BAP1 to the N-terminal region of FOXK2 in vivo was confirmed by co-IP of a GAL–FOXK2(1–218) fusion protein (Figure xref )."
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"The inclusion of ethidium bromide had no effect on FOXK2–BAP1 interactions (Figure xref ), demonstrating that the interactions are not DNA-mediated."
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"Both BAP1 and FOXK2 showed mobility changes, indicative of dephosphorylation, but there was no effect on FOXK2–BAP1 interactions (Figure xref )."
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"Furthermore, treatment of cells with the CDK inhibitor alsterpaullone had little effect on FOXK2–BAP1 interactions (Supplementary Figure S2C)."
24748658
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"Sites within this central region have been identified as important for binding non-ASXL complex components; for example, the HCF-binding motif and the phosphorylated threonine residue that mediates BAP1's interaction with FOXK2 have been mapped to this region [ xref , xref ]."
28202673
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"It therefore appears likely that the R58A mutation does more than affect phospho-dependent interactions but underscores the importance of this domain in mediating interactions between FOXK2 and BAP1."
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"Having established that FOXK2 and BAP1 interact in vivo , we next established whether they could bind to the same genomic regions."
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"Binding of both FOXK2 and BAP1 was detected at all of these regions while the control intronic region from the MCM3 locus exhibited binding levels close to background binding observed with control IgG."
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"For instance, during the G1/S transition, time at which the transcriptional activation of E2F target genes is critical, increased O-GlcNAcylation of FOXK1 might favor BAP1-FOXK1 complexes at the expense of BAP1-FOXK2 complexes."
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"Functional interactions between FOXK2 and BAP1 in target locus regulation."
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"Upon FOXK2 depletion (e.g. Supplementary Figure S6B), both FOXK2 and BAP1 binding was diminished at both the TP53I3 and H2AFX loci, indicating a role for FOXK2 in BAP1 recruitment (Figure xref )."
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"We also tested whether there was a reciprocal effect on FOXK2 binding upon BAP1 depletion but little effect was seen on the ChIP signal for FOXK2 following reductions in BAP1 expression levels by siRNA treatment (Figure xref ; Supplementary Figure S6B)."
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