IndraLab

Statements

Haem inhibits EIF2AK1. 2 / 2
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"Importantly, we identified that two pathways, one mediated by haem‐regulated inhibitor (HRI)/eIF2α and another by the RNase angiogenin (ANG), jointly convey this neuron‐specific shift to secure translational control during ER stress."
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"In this manner, SIFI turns off the ISR after a specific stress (that is, mitochondrial import defects) has been addressed, even though HRI can also be activated by protein aggregation, haem depletion or pathogen infection ."
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