IndraLab

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"These findings suggest that AML cells rely on broken redox sensing, instigated by USP15-KEAP1 repression of NRF2-mediated antioxidant programming."

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"COP1, along with numerous other ubiquitin ligases, is regulated by the COP9 signalosome; this protein complex is associated with the oxidative stress sensor Keap1 and the deubiquitinase USP15."