IndraLab

Statements

HIF1 activates USP22. 4 / 4
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"As a key regulator of hypoxia, HIF-1α contributes to HCC development by regulating USP22 and SENP1 to control HCC tumor growth and upregulating angiogenesis related genes."
36593103
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"In HCC cells with wild-type TP53 , p53 blocks the HIF-1α-induced upregulation of USP22."
33989708
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"As the direct target genes of HIF-1α, USP22 and TP53 can be upregulated by HIF-1α transcription in hypoxia."
35814827
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"Specifically, the hypoxia-mediated activation of HIF1α induced the upregulation of USP22, which in turn acted to deubiquitinate HIF1α, leading to the expression of HIF1α target genes, including glycolysis-related genes HK2, PDK1 and enolase 1 (ENO1) [123]."
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