IndraLab

Statements

USP25 activates KRAS. 6 / 6
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"Importantly, knockout (KO) of USP25 effectively suppresses tumor growth and RAS signaling in KRAS muts -driven autochthonous NSCLC mouse models and xenograft models, which is restored by additional deletion or inhibition of RNF31."
39952242
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"Indeed, USP21 expression restored macropinocytosis in Kras*-extinguished cells, and macropinocytosis inhibitors thwarted USP21-induced Kras* escape.Finally, to identify the direct target of USP21 activity, the investigators used the protein as bait to capture a single interacting culprit: MARK3, a microtubule-binding kinase and regulator of microtubule dynamics (Sandí et al. 2017)."
34599002
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"The deubiquitinase USP21 has been shown to promote KRAS∗-independent tumour growth by driving MARK3-dependent MP, which in turn maintains intracellular amino acid levels and activates mTORC1."
38626703
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"The USP21-mediated KRAS* bypass, coupled with the frequent amplification of USP21 in human PDAC tumors, encourages the assessment of USP21 as a novel drug target as well as a potential parameter that may affect responsiveness to emergent anti-KRAS* therapy."
34531315
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"The USP21-mediated KRAS* bypass, coupled with the frequent amplification of USP21 in human PAAD tumors, encourages the assessment of USP21 as a novel drug target that may impact responsiveness to emer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36328194
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"Using the inducible Kras /Trp53 PDAC mouse model, the same group subsequently identified that USP21 supported the growth of oncogenic KRAS-independent PDAC by elevating MARK3-mediated macropinocytosis (Hou et al., 2021)."
35846989