IndraLab

Statements

CTNNB1 increases the amount of LEF1. 30 / 30
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"Three of the identified regulators, Smad4, Atf2, and Beta-catenin, can activate Lef1 transcription ."
36243826
biopax:pid
No evidence text available
15728254
sparser
"Hypoxia-inducible factor 1α (HIF-1α) enhances β-catenin activation and expression of the downstream effectors LEF-1 and TCF-1 [ 24 ]."
32703426
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"Beta-CATENIN has been shown to activate LEF-1 transcription in regulating the expression of several EMT related genes during the EMT [XREF_BIBR], and FOXM1 has been shown to maintain the nuclear SMAD3 and SMAD4 complex [XREF_BIBR]."
25537512
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"1–3 ), we further tested the possibility that Lef1 expression could be synergistically regulated by interaction of β-catenin and NF-κB. Mouse chondrocytes were transfected with mock or constitutively [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17445771
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"Together, these results demonstrated that the level of FGF signaling dictates whether Wnt signaling transforms the NR to either the CM or the RPE fate.To understand the mechanism by which FGF signaling regulates Wnt activity, we examined Lef1 expression induced by the stabilized β-catenin."
34757798
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"Knockdown of Becn1 led to an increased expression of Lef1 from reprogramming day 5, suppressed expression of Wnt inhibitors including Sfrp1/2, and translocation of β-catenin into nucleus that subsequently transactivated downstream gene expression."
33087505
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"Thus, in the absence of beta catenin mediated canonical Wnt signaling, Bmp4 was insufficient to maintain Lef1 expression in the developing tooth mesenchyme and suggested that Lef1 mRNA expression is directly regulated by Wnt and beta catenin signaling in the developing tooth mesenchyme."
26604501
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"The Wnt and beta-catenin activation in CMs by Apc deletion increased Lef1 and Tcf7 levels, but suppressed Tcf7l2 expression."
30778164
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"Beta-catenin induces Axin2 and LEF1 transcription."
26257206
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"Canonical Wnts induce the accumulation of β-catenin, which promotes the expression of T-cell factor/lymphoid-enhancer binding factor-1 (Tcf/Lef)-dependent genes [12] , such as cyclin D1."
18588881
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"For example, HIF-1α modulates Wnt/β-catenin signaling in hypoxic embryonic stem cells by enhancing β-catenin activation and expression of the downstream effectors LEF-1 and TCF-1 [44] ."
36244535
sparser
"To understand the mechanism by which FGF signaling regulates Wnt activity, we examined Lef1 expression induced by the stabilized β-catenin."
34757798
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"15,16 Although transcription of both TCF-1 and LEF-1 is up-regulated by beta-catenin nuclear signaling, 15,16 it is not yet clear how the differential expression of their isoforms is controlled."
11839557
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"Inducible epithelial Wnt10a or beta-catenin deletion caused absence of nuclear, or all, beta-catenin, respectively (XREF_FIG), and loss of LEF1 and HOXC13 expression (XREF_FIG)."
28589954
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"Beta-catenin has been shown to activate LEF-1 transcription during EMT induced in vitro by c-Fos."
12095232
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"Furthermore, constitutively active beta‐catenin (Ctnnb1 ) had increased expression of targets Axin2 and Lef1, which were significantly reduced by osteoblast‐specific deletion of Foxo1 [63]."
37584250
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"Additionally, Hung et al. demonstrated that the Mg-mediated increased nuclear β-catenin binds with T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) to activate the canonical Wnt signalling pat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34534709
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"These data suggest that Lef1 mRNA expression is directly regulated by Wnt and beta-catenin signaling in the developing tooth mesenchyme."
19631205
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"Thus, FLAP1 enhanced LEF1 and TCF mediated transcription (XREF_FIG) and beta-catenin dependent transcription (XREF_FIG), while full-length Fli-I acted as a negative regulator of beta-catenin-dependent transcription (XREF_FIG)."
16990252
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"Moreover, Lef1 mediated transcription under basal conditions or stimulated by stabilization of beta-catenin by inactivating GSK3beta with LiCl is similar in scramble- and Cx43 silenced MLO-Y4 cells."
23483620
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"Activation of Wnt and beta-Catenin signaling increases the expression of ZNRF3 3, LEF1, Cyclin D1 36 and AXIN2, which are direct targets of beta-Catenin XREF_BIBR, XREF_BIBR, XREF_BIBR."
29872083
biopax:pid
No evidence text available
12052822
biopax:pid
No evidence text available
12582159
biopax:pid
No evidence text available
12582159
biopax:pid
No evidence text available
17893322
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"We conclude that low levels of β-catenin robustly synergize with Activin to up-regulate transcription at ME target genes but are insufficient to activate transcription of LEF1, AXIN, or other canonical Wnt target genes."
29269485
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"These data suggest that Wnt and beta-catenin signaling induces Lef1 expression, thereby decreasing Sema3A expression in odontogenic epithelial cells."
30862786
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"The systematic nuclear localization of beta-catenin in H5 derivatives that are dedifferentiated or that show imperfect restoration of the hepatic phenotype led us to investigate the expression of LEF-1, the nuclear partner of beta-catenin."
9472044
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"CTNNB1 activates Lef1 transcription and upregulates Lef1 promoter activity in vitro."
25033758