IndraLab

Statements

CTNNB1 increases the amount of LEF1. 19 / 19
5 | 14
reach
"Inducible epithelial Wnt10a or beta-catenin deletion caused absence of nuclear, or all, beta-catenin, respectively (XREF_FIG), and loss of LEF1 and HOXC13 expression (XREF_FIG)."
28589954
reach
"Knockdown of Becn1 led to an increased expression of Lef1 from reprogramming day 5, suppressed expression of Wnt inhibitors including Sfrp1/2, and translocation of β-catenin into nucleus that subsequently transactivated downstream gene expression."
33087505
biopax:pid
No evidence text available
15728254
biopax:pid
No evidence text available
12052822
reach
"CTNNB1 activates Lef1 transcription and upregulates Lef1 promoter activity in vitro."
25033758
reach
"These data suggest that Lef1 mRNA expression is directly regulated by Wnt and beta-catenin signaling in the developing tooth mesenchyme."
19631205
reach
"These data suggest that Wnt and beta-catenin signaling induces Lef1 expression, thereby decreasing Sema3A expression in odontogenic epithelial cells."
30862786
reach
"Thus, in the absence of beta catenin mediated canonical Wnt signaling, Bmp4 was insufficient to maintain Lef1 expression in the developing tooth mesenchyme and suggested that Lef1 mRNA expression is directly regulated by Wnt and beta catenin signaling in the developing tooth mesenchyme."
26604501
reach
"The Wnt and beta-catenin activation in CMs by Apc deletion increased Lef1 and Tcf7 levels, but suppressed Tcf7l2 expression."
30778164
reach
"Beta-catenin has been shown to activate LEF-1 transcription during EMT induced in vitro by c-Fos."
12095232
reach
"15,16 Although transcription of both TCF-1 and LEF-1 is up-regulated by beta-catenin nuclear signaling, 15,16 it is not yet clear how the differential expression of their isoforms is controlled."
11839557
biopax:pid
No evidence text available
17893322
biopax:pid
No evidence text available
12582159
reach
"Moreover, Lef1 mediated transcription under basal conditions or stimulated by stabilization of beta-catenin by inactivating GSK3beta with LiCl is similar in scramble- and Cx43 silenced MLO-Y4 cells."
23483620
reach
"Thus, FLAP1 enhanced LEF1 and TCF mediated transcription (XREF_FIG) and beta-catenin dependent transcription (XREF_FIG), while full-length Fli-I acted as a negative regulator of beta-catenin-dependent transcription (XREF_FIG)."
16990252
reach
"Activation of Wnt and beta-Catenin signaling increases the expression of ZNRF3 3, LEF1, Cyclin D1 36 and AXIN2, which are direct targets of beta-Catenin XREF_BIBR, XREF_BIBR, XREF_BIBR."
29872083
reach
"Beta-CATENIN has been shown to activate LEF-1 transcription in regulating the expression of several EMT related genes during the EMT [XREF_BIBR], and FOXM1 has been shown to maintain the nuclear SMAD3 and SMAD4 complex [XREF_BIBR]."
25537512
biopax:pid
No evidence text available
12582159
reach
"The systematic nuclear localization of beta-catenin in H5 derivatives that are dedifferentiated or that show imperfect restoration of the hepatic phenotype led us to investigate the expression of LEF-1, the nuclear partner of beta-catenin."
9472044