IndraLab

Statements

UCHL3 activates INS. 3 / 3
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"Furthermore, UCHL3 has deneddylating activity essential for various cellular functions and promotes insulin signaling and adipogenesis, hence contributing to retinal maintenance in stress conditions [15]."
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"These results suggest that UCH-L3 promotes adipogenesis by enhancing insulin signaling in a hydrolase activity dependent manner."
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"Suzuki et al. have shown that UCHL3 enhances insulin signalling in (pre) adipocytes, but UCHL3 is unlikely to target critical components of insulin signalling like the insulin receptor, the IGF-I receptor, IRS-1 and Grb10 XREF_BIBR."
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