IndraLab

Statements

TNFAIP3 inhibits MYD88. 4 / 4
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"However, our data indicate that this dysregulation can be further driven by TNFAIP3 loss in patients with MYD88 mutations.The importance of IL-6 and the autocrine mechanism by which IL-6 induces STAT3 activation in DLBCL has been shown in previous studies ."
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"We found that A20 can simultaneously inhibit MyD88 and TBK1 signals by binding Nrdp1, suggesting that Nrdp1 plays a key role in A20-mediated regulation of inflammatory signals."
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"Loss of TNFAIP3 enhances MYD88 -driven signaling in non-Hodgkin lymphoma, presenting a potential opportunity for therapeutic targeting (59)."
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"Using the MWCL-A20 and HBL-1-A20 , we were able to show that loss of TNFAIP3 enhances MYD88 -driven NF-κB and p38 signaling resulting in increased expression of NF-κB target genes IL-6 and CXCL10, known NF-κB target genes , have both been shown to be significantly upregulated in WM and DLBCL, and higher serum levels correlate with an inferior survival ."
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