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USP3 leads to the deubiquitination of CHEK1. 2 / 2
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"Herein, we show that the K63-linked ubiquitin chain at <span class="match term1">CHK1</span>'s K132 residue has an inhibitory effect on the kinase activity. Furthermore, we demonstrate that this modification can be removed by ubiquitin-specific protease 3 (<span class="match term0">USP3</span>), a deubiquitinating enzyme that targets K63-linked ubiquitin chains."
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"Multiple ubiquitin ligases, including the SKP1-CUL1-F-box (SCF) complex, CUL4-DDB1, and HUWE1 [ 89–93 ] can target CHK1 for proteasomal degradation, whereas the deubiquitinases USP1, USP3, USP7, and A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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