IndraLab

Statements

ITPR3 binds BAP1. 13 / 13
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"Cytoplasmic BAP1 binds to IP3R3 and promotes calcium ion release from the endoplasmic reticulum into the cytosol via IP3R3 deubiquitination, thereby inducing apoptosis."
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"Similarly, IP3R3 is bound and deubiquitinated by BRCA1-associated protein 1 (BAP1) at the ER [33] ."
29409699
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"For example, BAP1 binds to IP3R3 to deubiquitinate and promote apoptosis."
39161923
biogrid
No evidence text available
28614305
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"Overexpression of the N-terminus of the IP3R3 binds and sequesters BAP1 leading to decreased IP3R3 levels, an effect counter balanced by BAP1 co-overexpression (XREF_FIG)."
28614305
biogrid
No evidence text available
28614305
sparser
"Recently, a novel BAP1 cytoplasmic function was introduced, showing that ER-localized BAP1 can bind and stabilize IP3R3 to modulate Ca2+ release resulting in apoptosis [ xref ]."
31635116
sparser
"We confirmed the specificity of the BAP1 interaction with IP3R3 in HEK-293 cells expressing FLAG-BAP1 ( xref )."
28614305
biogrid
No evidence text available
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reach
"The data clearly indicated that BAP1 physically interacts with the type-3 inositol-1,4,5-trisphosphate-receptor (IP3R3), and BAP1 expression level is directly correlated with IP3R3 in wild-type and mutant fibroblasts."
28661472
biogrid
No evidence text available
28614305
sparser
"We found that BAP1 binds the N-terminus domain of IP3R3 [IP3R3(NT)] ( xref )."
28614305
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"Then BAP1 binds and deubiquitinates IP3R3 in the ER, leading to Calcium release into the cytosol and mitochondria, and initiation of apoptotic pathways."
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