IndraLab

Statements

OTUB1 binds TRAF6. 14 / 15
7 | 4 3
biogrid
No evidence text available
34591986
biogrid
No evidence text available
34591986
sparser
"Researchers found that OTUB1 directly binds to TRAF6 and removes K63-linked polyubiquitination modifications on TRAF6 through its deubiquitinating enzyme activity, an effect that inhibits TRAF6-mediated ubiquitination and activation of ASK1, which in turn down-regulates the expression of lipid metabolism-related genes (CD36, Fabp1, Scd1, PPARG and PPARα) and collagen-related genes (Col1a1, Col3a1, and α-SMA), which ultimately attenuated NASH ( xref )."
40292292
biogrid
No evidence text available
34591986
biogrid
No evidence text available
34591986
biogrid
No evidence text available
34591986
biogrid
No evidence text available
19996094
biogrid
No evidence text available
20622874
reach
"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
reach
"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63 linked polyubiquitin chains."
33511009
reach
"Coimmunoprecipitations indicated OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus triggered IRF3 and NF-kappaB activation, respectively."
19996094
reach
"In contrast, we did not detect any interactions between OTUB1 and IRAK1, Pellino, or TRAF6 (Supplementary Fig. 3a)."
32024978
sparser
"OTUB1 directly binds to TRAF6, suppresses its K63-linked ubiquitination, and inhibits the activation of ASK1 and the JNK/p38 pathway under MASH conditions ( xref )."
40754778
sparser
"A20 was shown to directly interact with TRAF6 [48] and the OTU domain is involved in removing K63-linked polyubiquitin chains from TRAF6 [49] ."
24103590