IndraLab

Statements

OTUD3 activates Carcinogenesis. 12 / 12
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"A previous study demonstrated that OTUD3 promotes lung tumorigenesis by stabilizing GRP78 [26]."
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"Our previous study confirmed that OTUD3 promotes lung tumorigenesis by stabilizing the substrate GRP78 [2]."
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"These results suggested that OTUD3 may promote tumorigenesis in leukemia ."
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"These results suggested that OTUD3 may promote tumorigenesis in leukemia."
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"OTUD3 is a member of the OTU family that participates in the regulation of multiple physiological processes, and the aberrant expression of OTUD3 triggers tumorigenesis in esophageal cancer, breast cancer and papillary thyroid carcinoma (87,88)."
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"Our previous study indicated that OTUD3 promoted lung tumorigenesis through stabilizing the glucose-regulated protein 78 kDa (GRP78) [2, 17]."
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"OTUD3 can stabilize Bip and promote lung tumorigenesis [40], whereas it suppresses breast tumorigenesis through stabilizing the PTEN protein [42]."
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"Remarkably, OTUD3 promotes lung tumorigenesis by stabilizing the glucose-regulated protein 78 kDa (GRP78) [26], which is a multifunctional protein with activities far beyond its well-known role in controlling unfolded protein response and implicated in promoting tumor proliferation, metastasis and involved in drug resistance [30–36]."
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"OTUD3 promotes lung tumorigenesis by stabilizing GRP78 [44], while it stabilizes ACTN4 to drive hepatocellular carcinoma progression and metastasis [45]."
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"OTUD3 is a potential tumor suppressor in NSCLC, a deubiquitylase of GRP78, and promotes tumorigenesis of NSCLC (89)."
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"The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer."
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"The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer."
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