IndraLab

Statements

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"miR-135b promoted cell proliferation and glycolysis that could be reversed by the overexpression of USP13 or PTEN."
25571954
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"Accordingly, we propose that USP13 inhibits the proliferation and glycolysis of OSCC cells via the upregulation of PTEN and the downregulation of AKT activity."
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"Zhang et al. reported that USP13 suppresses tumorigenesis and glycolysis in PTEN-positive breast cancer through the deubiquitination of PTEN [18]."
40319251
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"USP13 overexpression inhibited the proliferation of and glycolysis in OSCC cells in vitro and suppressed tumorigenesis in nude mice."
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"Conversely, overexpression of USP13 suppresses tumorigenesis and glycolysis in PTEN positive but not PTEN-null breast cancer cells."
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"USP13 deficiency promotes glucose uptake and glycolysis (51)."
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"In this study, we identified USP13 as the first deubiquitinase that reverses PTEN poly-ubiquitination and stabilizes PTEN protein, and found that USP13 suppresses tumorigenesis and glycolysis through PTEN."
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"These data suggested that USP13 overexpression inhibited glycolysis in OSCC cells."
31802942
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"Indeed, knockdown of USP13 increased glucose uptake and glycolysis, which could be fully reversed by restoration of PTEN, as gauged by lactate production and glucose incorporation assays (XREF_FIG)."
24270891
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"For example, overexpression of USP13 blocks the AKT signaling pathway and suppresses tumor cell proliferation, invasion, and glycolysis by upregulating PTEN, while USP13 levels are downregulated in breast, bladder, and oral squamous tumors, in correlation with PTEN levels (Fig. 3)."
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"Our data together with previous reports suggest the important context-specific role of USP13 in tumorigenesis.To explore the mechanism by which USP13 inhibited glycolysis in OSCC cells, we examined its effects on AKT signaling, which is known to be activated by USP13."
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"Ectopic expression of USP13 suppressed cell proliferation, glycolysis, and tumorigenicity."
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"Then, we explored the effects of USP13 on aerobic glycolysis and found that silencing USP13 in OS cells decreased levels of extracellular acidification rate (ECAR, Fig. 1e) and reduced glycolysis and glycolytic capacity (Fig. 1f)."
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