IndraLab

Statements

SCN9A activates calcium(2+). 3 / 3
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"SymRK (23, 24), nucleoporins NUP85 (25), NUP133 (26), and NENA (27), potassium channels Castor and Pollux (28–30), and calcium channels of the CNGC15 family (31) all act upstream of NF-induced perinuclear calcium oscillations."
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"Taken together, our work delineates a new pathway, which involves the NF-kappaB transcription factor, SCN9A expression, plasma membrane depolarization, increased calcium, the Rb/E2F pathway and mitotic gene repression in the regulation of senescence."
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"Similarly, the selective inhibition of Nav1.7 also significantly reduced the calcium fluorescence intensity (***p < 0.001), further indicating that Nav1.7‐mediated sodium influx may be an important driving force influencing NCX1 reverse‐mode transport."
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