IndraLab

Statements

Lapatinib inhibits KCNH2. 3 / 3
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eidos
"Since the cycle length of the sinus rate was about 600 ms in this study , the prolongation patterns in each MAP90 were likely the reverse use-dependent manner , indicating that lapatinib might inhibit the hERG current ."
31959820
reach
"Lapatinib can block the HERG channel in transfected HEK293 cells and prolong the action potential duration [XREF_BIBR], prolonging the QT interval."
29876021
reach
"In ion channel studies, lapatinib inhibited the hERG current in a concentration dependent manner, with a half-maximum inhibition concentration (IC (50)) of 0.8 +/- 0.09 microm."
20406211