IndraLab

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KN-93 inhibits BAP1. 5 / 5
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"This result suggests that KN-93 selectively suppresses the proliferation of BAP1 cells with CAMK2D-positive expression."
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"KN-93 induces significant apoptosis in BAP1-deficient cells."
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"Similarly, the cleaved PARP level was markedly increased in the KN-93-treated BAP1 cells (Fig. 5b), suggesting that KN-93 suppresses the proliferation of BAP1 cells by promoting apoptosis."
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"Hence, we propose that KN-93 promotes apoptosis in BAP1-negative MMe cells by increasing intracellular Ca concentrations, most likely by inhibiting CAMK2D activity."
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"CAMKII inhibitor KN-93 selectively suppresses the proliferation of BAP1-deficient mesothelioma cells."
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