IndraLab

Statements

COPS5 activates HIF1A. 3 / 8
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"Second, in a manner independent of the CSN holocomplex, CSN5 (or a CSN5 containing small complex) promotes cell proliferation by inducing p27 degradation [22,23] and HIF1-alpha stabilization [41]."
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"While Jab1 promotes HIF-1alpha stability and transactivation, p53 degrades HIF-1a and decreases its transactivation."
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"However, in contrast to the studies involving MIF regulation of the SCF complex resulting in enhanced degradation and decreased stability of p27 and Cdc25A proteins, MIF and CSN5 regulates HIF-1alpha turnover resulting in enhanced stability and decreased degradation of HIF-1alpha."
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