IndraLab

Statements

USP8 increases the amount of RNF41. 4 / 4
1 | 3
reach
"Furthermore, in a previous study, USP8 increased NRDP1 levels, potently downregulated MyD88 and TLR4 levels, and blocked inhibitor of NF-κB kinase subunit β and IκBα phosphorylation, thus decreasing p65 nuclear translocation, resulting in and inhibition of NF-κB signaling pathway activation in LPS-induced mice (12)."
36321796
reach
"We hypothesized that USP8 could increase the expression of Nrdp1 and inhibit neuroinflammation by modulating the TLR4-mediated MyD88-dependent pathway."
32335193
signor
"Ubiquitin-specific protease 8 (USP8), an RNF41-interacting deubiquitylating enzyme (DUB) stabilizes RNF41 and is involved in trafficking of various transmembrane proteins."
23750007
reach
"Since we found that USP8 treatment increased the Nrdp1 levels in LPS-induced mice ( Fig. 4 D), we speculate that this may downregulate the expression of TLR4 and MyD88 protein, and subsequently inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32335193