IndraLab

Statements


VCPIP1 inhibits VCP. 3 / 3
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"During mitosis, Cdk1 phosphorylates p47, p37 and VCIP135, and blocks p97 controlled membrane-fusion processes so that the Golgi membranes remain disassembled."

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"Our in vitro Golgi reassembly assay confirmed that VCIP135 phosphorylation at S130 attenuates p97 and p47 mediated Golgi membrane fusion (XREF_FIG)."

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"In the presence of ATP, the addition of VCIP135 prevented p97 and p47 from binding to syntaxin5 and VCIP135 itself only bound poorly to syntaxin5 (XREF_FIG D, left three lanes)."