IndraLab

Statements

NAC inhibits NFKBIA. 3 / 3
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"Our findings suggested that NF-κB proteins were downstream of ROS since NAC inhibited nicotine-induced IκBα and p65 phosphorylation."
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"As shown in XREF_FIG, NAC pre-treatment blocked TQ induced down-regulation of NFkappaB targets; IkappaBalpha, Bcl-2 and Survivin confirming the mode of action of TQ being ROS release in ABC cells."
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"Since ROS is an upstream signal for NF-kappaB, we found that NAC pre-treatment significantly diminished p-IkappaBalpha lever and IkappaB protein degradation induced by CM-LA."
| PMC