IndraLab

Statements

USP15 activates NFE2L2. 3 / 3
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"circADAM9 targets miR-545-3p, which enhances the expression of the deubiquitinating enzyme USP15, activates the Keap1/Nrf2 pathway and leads to a more severe onset of fibrosis 171."
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"Inhibition of USP15 and subsequent activation of NRF2 leads to redox perturbations in AML cells, coincident with impaired leukemic cell function."
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"The absence of USP15 reduced oxidative stress in MCAO mice and attenuated ferroptosis by activating nuclear factor erythroid 2-related factor 2 (Nrf2)."
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