IndraLab

Statements

Silibinin inhibits RELA. 5 / 6
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"Results indicated that compared to their respective controls, the immunoreactivity score of total p65 decreased by 28% in silibinin fed LoVo xenografts (P < 0.05), whereas the decrease was 75% (P < 0.001) in case of SW480 (XREF_FIG)."
22086675
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"Interestingly, silibinin can block p65 NF-κB migration, and its neuroprotective effect is closely related to the AKT/mTOR signaling pathway ( Wang et al., 2012 )."
35513214
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"Western immunoblot analysis further showed that silymarin reduced p65 in the nucleus (XREF_FIG)."
25954125
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"In vivo studies conducted in mouse models indicate that topical application of silibinin inhibits UVB induced expression levels of ERK1/2 and p38 proteins of MAPK family, and subsequently inhibited the activation of NF-kappaB and p65 through inhibition of degradation of IkappaBalpha and activation of IKKalpha."
20372777
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"As observed from Figure 6, silibinin and capsaicin pre-treatment alone could down-regulate the activation of LPS-induced NF-κB (p65) by 44.8 and 51.7%, respectively."
35844639