IndraLab

Statements

USP28 activates BRAF. 2 / 2

| 2

reach

"As USP28 deubiquitinates and stabilizes FBW7, allowing the FBW7 and SCF ligase complex to bind and degrade substrates containing a Cdc4 phosphodegron motif, we hypothesized that forced expression of USP28 would target BRAF for degradation."

29880484

➶

reach

"As expected USP28 mediated BRAF stability led to enhanced pERK levels after vemurfenib treatment compared with wild-type USP28 cells."

29880484

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP28 activates BRAF. 2 / 2

INDRA sources:

Databases

Reading