IndraLab

Statements

USP28 activates BRAF. 3 / 3
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"As USP28 deubiquitinates and stabilizes FBW7, allowing the FBW7 and SCF ligase complex to bind and degrade substrates containing a Cdc4 phosphodegron motif, we hypothesized that forced expression of USP28 would target BRAF for degradation."
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"As expected USP28 mediated BRAF stability led to enhanced pERK levels after vemurfenib treatment compared with wild-type USP28 cells."
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"Therefore, the attenuation of BRAF and MAPK signaling caused by USP28 can inhibit EMT as well [16]."
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