IndraLab

Statements

USP4 binds MAVS. 7 / 7
1 | 6
biogrid
No evidence text available
30410068
sparser
"Notably, overexpression of USP4 did not increase the expression of the shorter MAVS, suggesting that this regulation may be dependent on the interaction of USP4 with the MAVS N-terminal region."
39589880
sparser
"First, we verified the interaction between USP4 and MAVS during virus infection through the use of a coimmunoprecipitation assay ()."
39589880
sparser
"Subsequently, we found that overexpression of PBLD significantly augmented the interaction between USP4 and MAVS in the context of viral infection ( xref ), but PBLD did not directly target USP4 ()."
39589880
sparser
"To identify the domain involved in the interaction between USP4 and MAVS, we created truncation mutants of USP4 and MAVS ( xref )."
39589880
sparser
"In addition, the interaction between MAVS and USP4 was found to depend on the N-terminal DUSP domain of USP4, whereas the C-terminal USP domain was not implicated ( xref )."
39589880
sparser
"As a DUB, USP4 binds to MAVS via its DUSP domain and subsequently inhibits its K48-linked ubiquitination-mediated degradation to maintain the stability of the MAVS protein."
39589880