IndraLab

Statements


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sparser
"We next examined whether BAP1 binds to NUMB and whether this association regulates N1ICD stability."

sparser
"First, both exogenously expressed and endogenous BAP1 could bind to endogenous NUMB ( xref )."

sparser
"Our results demonstrate that Jagged1 not only induces Notch1 activation in retinal endothelial cells but also regulates its deubiquitylation and stabilization via its interaction with Numb and BAP1."

sparser
"Third, similar to N1ICD, NUMB could bind to BAP1 N-terminal or C-terminal part ( xref )."

sparser
"IL-33 enhances Notch1 intracellular domain deubiquitination via its interaction with Numb and BAP1."