IndraLab

Statements

USP15 activates MDM2. 5 / 8
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"These results suggest that USP15 prevents the ubiquitin dependent degradation of MDM2 in activated T cells."
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"We next examined whether USP15 directly targets MDM2."
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"We found that USP15 mediates the stability of MDM2 in both T cells and cancer cells."
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"Because of the ubiquitin dependent degradation, together with TCR and CD28 stimulation, MDM2 can be transiently down-regulated, and the loss of USP15 greatly promotes the degradation of MDM2 in T cells."
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"In both activated T cells and cancer cells, loss of USP15 caused MDM2 degradation."
24777531