IndraLab

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DPP6 activates KCND2. 4 / 8
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"DPP6 functions as a regulator of the channels ' recovery rate and voltage dependency 37 and promotes the cell surface localization of KCND2 38, besides other functions that remain to be identified 39."
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"Functionally, DPPX has been thought to mediate both membrane expression of Kv4.2 channels and signal conductance, thereby modulating dendritic excitability [1]."
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"Indeed, charge neutralization mutations affecting these two amino acids (D18N, E20Q) abolished DPP6-induced increase in Kv4.2 γ without impacting additional macroscopic properties [58]."
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"The DPP6 auxiliary subunit establishes the Kv4.2 functional gradient in CA1 pyramidal neurons through enhanced dendrite-directed surface expression and increased availability of Kv4.2 at hyperpolarized membrane potentials, particularly in distal dendrites (Hoffman et al., 1997; Sun et al., 2011)."
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