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Ibrutinib inhibits NLRP3. 14 / 14
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"For example, ibrutinib, a Bruton's tyrosine kinase inhibitor, can inhibit NLRP3 inflammasome, caspase-1 and IL-1β activation, thereby alleviating cerebral I/R injury ."
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"A study from Song et al., for example, found that Bruton’s tyrosine kinase (BTK) inhibitor, ibrutinib, is able to reduce ischemia–reperfusion injury by suppressing the activation of the NLRP3 inflammasome in KCs [92] (Table 3)."
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"Corroborating the genetic evidence that BTK is a positive regulator of NLRP3 signaling, treatment with ibrutinib or acalabrutinib suppresses NLRP3- but not AIM2-induced inflammasome activation and blocks IL-1β processing in human and mouse macrophages or TAMs in vitro as well as in vivo in mouse models of ischemic brain injury, polymicrobial sepsis and bacterial infection (Ito et al., 2015; Liu et al., 2017; Benner et al., 2019; de Porto et al., 2019; O’Riordan et al., 2019; Weber, 2021)."
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"Other research demonstrates that ibrutinib reduces the activation of NF-κB and NLRP3 inflammasomes by targeting BTK and finally ameliorates pulmonary inflammation [37], suggesting that BTK might be a potential drug target for anti-inflammation."
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"We tested whether ibrutinib and acalabrutinib, a new generation BTK inhibitor with higher selectivity, require BTK to inhibit the NLRP3 inflammasome, metabolic inflammation and blood glucose in obese mice."
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"Bruton’s tyrosine kinase (BTK) is mainly expressed on KCs and sinusoidal endothelial cells, and BTK inhibitor ibrutinib effectively attenuates liver I/R injury by suppressing activation of the NLRP3 inflammasome in KCs (52)."
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"Purvis et al. (46) showed that ibrutinib treatment also attenuated the activation NLRP3 inflammasome in the diabetic kidney and liver."
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"Interestingly, Ito and coworkers [XREF_BIBR] showed that ibrutinib (PCI-32765), a potent BTK inhibitor [XREF_BIBR], suppresses NLRP3 inflammasome signal in a focal brain I/R model."
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"Interestingly, Ito and coworkers [XREF_BIBR] showed that ibrutinib (PCI-32765), a potent BTK inhibitor [XREF_BIBR], suppresses NLRP3 inflammasome signal in a focal brain I/R model."
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"The youngest, Ibrutinib, used to treat mantle cell lymphoma, was also found to block the NLRP3 inflammasome in an animal model of ischemic stroke (Ito et al., 2015; Liu et al., 2017)."
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"We observed that ibrutinib inhibited the induction of NLRP3 in physically stressed mice, as compared to control group of mice."
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"We observed that Ibrutinib inhibited the induction of NLRP3 in physically stressed mice, as compared to control group of mice."
| DOI
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"Cardiac NLRP3 Activation in CLP Mice Is Reduced by Ibrutinib or Acalabrutinib."
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"This allows precise and efficient ibrutinib delivery, concurrently inhibiting the activation of the NF-κB pathway in B cells and the NLRP3 inflammasome in macrophages within the plaques."
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