IndraLab

Statements

Ibrutinib inhibits NLRP3. 10 / 10
| 10
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"Purvis et al. (46) showed that ibrutinib treatment also attenuated the activation NLRP3 inflammasome in the diabetic kidney and liver."
33162995
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"We observed that ibrutinib inhibited the induction of NLRP3 in physically stressed mice, as compared to control group of mice."
34895246
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"Interestingly, Ito and coworkers [XREF_BIBR] showed that ibrutinib (PCI-32765), a potent BTK inhibitor [XREF_BIBR], suppresses NLRP3 inflammasome signal in a focal brain I/R model."
27127546
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"Corroborating the genetic evidence that BTK is a positive regulator of NLRP3 signaling, treatment with ibrutinib or acalabrutinib suppresses NLRP3- but not AIM2-induced inflammasome activation and blocks IL-1β processing in human and mouse macrophages or TAMs in vitro as well as in vivo in mouse models of ischemic brain injury, polymicrobial sepsis and bacterial infection (Ito et al., 2015; Liu et al., 2017; Benner et al., 2019; de Porto et al., 2019; O’Riordan et al., 2019; Weber, 2021)."
34485307
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"As expected, ORF3a protein was expressed in infected HEK-293T and A549 cells, The youngest, Ibrutinib, used to treat mantle cell lymphoma, was also found to block the NLRP3 conserved in all isolates, also resulted in a dampened response by the inflammasome (Fig.7B , right 222 panel)."
35066302
reach
"Interestingly, Ito and coworkers [XREF_BIBR] showed that ibrutinib (PCI-32765), a potent BTK inhibitor [XREF_BIBR], suppresses NLRP3 inflammasome signal in a focal brain I/R model."
27127546
reach
"Delayed administration of ibrutinib and acalabrutinib attenuated the decline of EF, FS, and FAC caused by CLP and also reduced the activation of BTK, NF-kappaB, and NLRP3 inflammasome."
31552054
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"Cardiac NLRP3 Activation in CLP Mice Is Reduced by Ibrutinib or Acalabrutinib."
31552054
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"The youngest, Ibrutinib, used to treat mantle cell lymphoma, was also found to block the NLRP3 inflammasome in an animal model of ischemic stroke (Ito et al., 2015; Liu et al., 2017)."
35066302
reach
"We observed that Ibrutinib inhibited the induction of NLRP3 in physically stressed mice, as compared to control group of mice."
| DOI