IndraLab

Statements

reach
"In cardiac cells exposed to ischemic conditions, in CME-induced excessive ROS generation, and in MI rats, rosuvastatin and LCZ696 were shown to effectively suppress ROS production and subsequently inhibit NLRP3-mediated pyroptosis43 53."
36815034
reach
"Similarly, rosuvastatin was found to reduce cardiac dysfunction in DCM rats by inhibiting NLRP3 inflammasomes [53]."
36871006
reach
"Furthermore, rosuvastatin significantly inhibited the activation of NLRP3 inflammasome in this animal model."
29568858
reach
"It has been showed that rosuvastatin and fenofibrate suppress the inflammatory process of cardiovascular disease by inhibiting NLRP3 inflammasome [6,31] ."
27614220
reach
"Rosuvastatin and other statins have been proven to attenuate inflammation and DCM via NLRP3 inflammasome and MAPK signaling pathways (57)."
36582738
reach
"This finding indicated that application of high dose of rosuvastatin could downregulate NLRP3 and its downstream effectors, thus alleviate inflammatory response in atherogenesis (Altaf et al., 2015)."
35493086
reach
"Both ticagrelor and rosuvastatin reduced postinfarction activation of NLRP3 inflammasome [136]."
34123416
reach
"Furthermore, spironolactone and rosuvastatin, the two-hit anti-inflammatory agents, reduced NLR family pyrin domain containing 3 (NLRP3)/GSDMD pyroptosis in EAT and autophagy in myocardium of HFpEF mouse."
36356543
reach
"Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin."
38262148
reach
"Luo et al. 28 indicated that rosuvastatin, a type of anti-hyperlipidemic agent, inhibited the NLRP3 inflammasome via the MAPK pathway in DCM."
31182921