IndraLab

Statements

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"Furthermore, REST overexpression in NPCs rescues the differentiation phenotype induced by HAUSP knockdown."
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"USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities."
37196079
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"Knockdown of USP7 inhibits osteogenic differentiation of hASCs in vitro."
28807012
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"In contrast, most cells targeted with shHAUSP became TUJ1 positive and only rarely remained Nestin positive (XREF_FIG, bottom panel), suggesting that targeting HAUSP induced neuronal differentiation."
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"Furthermore, REST overexpression in NPCs rescued the differentiation phenotype induced by HAUSP knockdown."
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"Here we show that the deubiquitylase HAUSP counterbalances REST ubiquitylation and prevents NPC differentiation."
21258371
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"Knockdown of USP7 or USP7 inhibitor HBX 41,108 application suppresses osteogenic differentiation of hBMMSCs."
28807012
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"Although HAUSP has several molecular targets, the ability to rescue the effects of HAUSP modulation on NPC maintenance and differentiation by REST expression indicates that HAUSP functions largely through REST to prevent NPC differentiation."
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"HAUSP knockdown in neural progenitor cells induces neuronal differentiation and disrupts self-renewal."
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"HAUSP knockdown in NPCs decreases REST and induces differentiation."
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"Collectively, these data demonstrate that HAUSP functions largely through REST to prevent NPC differentiation."
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"Our study demonstrates that USP7 harbors both catalytic and noncatalytic activities to repress different lineage differentiation genes, thereby revealing a previously unrecognized role in controlling gene expression for maintaining mESC identity."
37196079
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"Here we show that deubiquitinase HAUSP counterbalances REST ubiquitination and prevents NPC differentiation."
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"Indeed, quantified data indicate that HAUSP knockdown significantly increased the proportion of differentiated cells (XREF_FIG), suggesting that HAUSP deubiquitinase prevents NPC differentiation."
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"Immunofluorescent staining showed that ectopic expression of Wt-HAUSP but not the Mt-HAUSP almost fully rescued the differentiation phenotype induced by knockdown of endogenous HAUSP with the B5 shHAUSP (XREF_FIG)."
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"In summary, these data indicated that, analogous to its effect on hASCs, USP7 deficiency inhibits osteogenic differentiation of hBMMSCs."
28807012
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"Knockdown of USP7 or USP7 inhibitor HBX 41,108 application inhibits adipogenic differentiation of hASCs in vitro."
28807012
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"Functional disruption of HAUSP in NPCs reduces REST protein and induces neuronal differentiation."
22569092
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"These data indicate that ectopic expression of REST largely overrode the cell differentiation induced by HAUSP knockdown."
21258371
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"HAUSP knockdown in NPCs decreased REST and induced differentiation."
23483195
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"Knockdown of USP7 significantly reduced the osteogenic differentiation manifested by both ALP and Alizarin red S staining and quantification."
28807012