IndraLab

Statements

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"HAUSP knockdown in NPCs decreases REST and induces differentiation."
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"Silencing of USP7 induces neuronal differentiation, while overexpression stabilizes REST protein and promotes neuronal progenitor stem cell maintenance (26)."
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"Furthermore, REST overexpression in NPCs rescued the differentiation phenotype induced by HAUSP knockdown."
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"Immunofluorescent staining showed that ectopic expression of Wt-HAUSP but not the Mt-HAUSP almost fully rescued the differentiation phenotype induced by knockdown of endogenous HAUSP with the B5 shHAUSP (XREF_FIG)."
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"Knockdown of USP7 inhibits osteogenic differentiation of hASCs in vitro."
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"Furthermore, REST overexpression in NPCs rescues the differentiation phenotype induced by HAUSP knockdown."
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"Knockdown of USP7 or USP7 inhibitor HBX 41,108 application suppresses osteogenic differentiation of hBMMSCs."
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"Knockdown of USP7 significantly reduced the osteogenic differentiation manifested by both ALP and Alizarin red S staining and quantification."
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"In summary, these data indicated that, analogous to its effect on hASCs, USP7 deficiency inhibits osteogenic differentiation of hBMMSCs."
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"Knockdown of USP7 or USP7 inhibitor HBX 41,108 application inhibits adipogenic differentiation of hASCs in vitro."
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"HAUSP knockdown in neural progenitor cells induces neuronal differentiation and disrupts self-renewal."
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"43 In conclusion, our study demonstrated that up-regulation of miR-15b could inhibit the expression of USP7, which potentially suppress the osteoblast proliferation, differentiation and autophagy to aggravate osteoporosis through inhibition of KDM6B expression."
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"In contrast, most cells targeted with shHAUSP became TUJ1 positive and only rarely remained Nestin positive (XREF_FIG, bottom panel), suggesting that targeting HAUSP induced neuronal differentiation."
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"Although HAUSP has several molecular targets, the ability to rescue the effects of HAUSP modulation on NPC maintenance and differentiation by REST expression indicates that HAUSP functions largely through REST to prevent NPC differentiation."
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"Indeed, quantified data indicate that HAUSP knockdown significantly increased the proportion of differentiated cells (XREF_FIG), suggesting that HAUSP deubiquitinase prevents NPC differentiation."
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"In the future, it would be better to use an Ihh-specific inhibitor.In conclusion, our study indicated that USP7 knockdown or its inhibition inhibits chondrocyte proliferation and chondrogenic differen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data indicate that ectopic expression of REST largely overrode the cell differentiation induced by HAUSP knockdown."
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"Beyond our proven hypothesis that Usp7 RNAi inhibited cell proliferation and differentiation of the regenerative worms, we wondered how cell apoptosis would be affected by Usp7 deficiency during regeneration."
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"Collectively, these data demonstrate that HAUSP functions largely through REST to prevent NPC differentiation."
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"Functional disruption of HAUSP in NPCs reduces REST protein and induces neuronal differentiation."
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"Knockdown of USP7 inhibits chondrogenic differentiation of ATDC5 cells but promotes hypertrophic differentiation [23]."
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"USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities."
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"USP7 inhibition reprograms tolerogenic DCs to promote Th17 while restraining Th2 and Treg differentiation."
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"Our study demonstrates that USP7 harbors both catalytic and noncatalytic activities to repress different lineage differentiation genes, thereby revealing a previously unrecognized role in controlling gene expression for maintaining mESC identity."
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"Furthermore, knockout of the Usp7 gene particularly elevated the expression of neuronal differentiation related genes including astryocyte-specific markers and oligodendrocyte-specific markers."
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"Experimental results showed that USP7 overexpression suppressed the expression of several pathway-related genes, including Wnt, promoting cellular EMT and inhibiting cellular senescence and differentiation (128–130)."
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"These results suggest that USP7 represses lineage differentiation genes and maintains cell metabolism–associated genes in mESCs.To further test the role of its catalytic activity in maintaining mESCs, we then treated mESCs with P22077, a known USP7 enzymatic inhibitor (33)."
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"To further elaborate the ability of USP7 to repress lineage differentiation genes, we performed Usp7 depletion or its catalytic activity inhibition by shRNA or P22077 treatment in mESCs, respectively, and analyzed gene expression."
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"Here we show that deubiquitinase HAUSP counterbalances REST ubiquitination and prevents NPC differentiation."
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"Our in vivo data demonstrated that high USP7 expression by tolerogenic DCs of NOD.Stat5b-CA mice is necessary for the induction and maintenance of Th2 response and Tregs differentiation and that USP7 inhibition reprograms tolerogenic DCs to promote more Th17 while restraining Th2 and Tregs differentiation."
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"HAUSP knockdown in NPCs decreased REST and induced differentiation."
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