IndraLab

Statements

USP25 activates Wnt. 18 / 19
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"Wang et al38 reported that knockout of USP25 attenuated Wnt and SOCS3–pSTAT3 signaling, leading to suppression of colon tumorigenesis."
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"USP21 activates Wnt/beta-Catenin signaling to accelerate ESCC progression in a G3BP1-dependent manner."
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"Moreover, it has been observed that USP25 inhibition attenuates Wnt and SOCS3-pSTAT3 signaling, which is known to inhibit colonic tumorigenesis [ 17 , 18 ]."
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"USP21 has been shown to enhance Wnt signaling through deubiquitylation and stabilization of the long isoform of transcription factor TCF7, which belongs to the TCF/LEF family and mediates oncogenic activation of Wnt signaling (Figure 3) (Shiokawa et al., 2017; Hou et al., 2019)."
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"As an oncogene, USP21 enhances CSC stemness by activating the Wnt pathway, resulting in tumor progression [12]."
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"This suggests that USP25 acts as a DUB of tankyrase to stabilize tankyrase and induce a positive process of Wnt and beta-catenin signaling [XREF_BIBR]."
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"In human pancreatic ductal adenocarcinoma, USP21 activated the Wnt pathway to promote the stemness of cancer cells by acting as a deubiquitinase of TCF7 [24]."
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"In this study, we show that ubiquitin-specific protease 25 (USP25), a deubiquitinating enzyme (DUB), positively regulates Wnt signaling by mediating the deubiquitination of tankyrases."
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"USP25 modulates the Wnt/beta-catenin pathway through tankyrases."
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"Since we found that USP25 could stabilize tankyrases, we reasoned that USP25 might modulate the Wnt pathway through up-regulating tankyrases to promote the degradation of Axin."
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"We found that knockdown of USP25 significantly reduced this Wnt-driven luciferase activity (Fig. 5B)."
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"USP25 promotes HCC growth by activating the Wnt/beta-catenin signaling pathway ."
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"These results indicated that USP25 regulates Wnt signaling via modulation of tankyrase/Axin.To investigate the effects of the USP25–tankyrase interaction on Wnt signaling, wild-type USP25 as well as the R1049A and G1054A mutants were introduced into Usp25 HEK293T cells individually (Supplemental Fig. S5D), and we found that the expression of wild-type USP25, but not these mutants, restored the STF activity in Usp25 HEK293T cells (Fig. 5J), suggesting that USP25 modulates the Wnt pathway through the interaction with tankyrases."
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"For instance, USP21 stimulates the stemness of pancreatic cancer cells by activating the Wnt pathway."
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"Since only nuclear USP21 activated the Wnt pathway genes, we next explored the Wnt pathway components that either reside in the nucleus or shuttle between the cytoplasm and nucleus in iKPC cells, including β-catenin, Dishevelled proteins and TCF/LEF transcription factors ()."
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"Nuclear USP21 activates Wnt/beta-catenin pathway and promotes cancer cell stemness."
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"Thus, nuclear USP21 up-regulates Wnt pathway signaling and promotes tumor-initiating potential in PDAC cells."
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"Overexpression of USP25 activates Wnt signaling and enhances CRC tumorigenesis."
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