IndraLab

Statements

USP15 binds APC. 8 / 8
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"In addition, NKD1 can promote the ubiquitination degradation of APC by inhibiting the binding of APC to the deubiquitinating enzyme USP15."
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"Thus, the CSN controls the Wnt and beta-catenin signalling by assisting the assembly of beta-catenin-degrading supercomplexes by deneddylation and, simultaneously, by stabilising APC via CSN associated USP15."
19576224
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"NKD1 promotes the ubiquitination degradation of APC by prohibiting the expression of USP15 and blocking binding of the deubiquitinating enzyme USP15 to APC and leads to the entry of β‐catenin into the nucleus to promote colon cancer cell proliferation, migration, and invasion, while let‐7b‐5p inhibits this process by targeting NKD1 (Figure  xref )."
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"CSN controls Wnt and beta-catenin signaling by assisting with the assembly of beta-catenin-degrading supercomplexes by deneddylation and, simultaneously, by stabilizing APC via CSN associated USP15."
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"A model is provided that proposes a role of CSN mediated deneddylation in the formation of the beta-catenin-degrading supercomplex and the protection of complex bound APC via CSN associated USP15."
19576224
biogrid
No evidence text available
36445120
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"In addition, immunoprecipitation assays demonstrated that the binding of USP15 to APC was remarkably blocked by the NKD1 overexpression, while the combination between APC and USP15 was notably enhanced through knocking down NKD1 (Figure 9D)."
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"In addition, immunoprecipitation assays demonstrated that the binding of USP15 to APC was remarkably blocked by the NKD1 overexpression, while the combination between APC and USP15 was notably enhanced through knocking down NKD1 (Figure  xref )."
36445120