IndraLab

Statements

FGF18 decreases the amount of USP21. 4 / 4
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"Interestingly, FGF18 overexpression significantly decreased the expression of USP16 in mice (Fig. S4A)."
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"The enrichment of Nrf2 at USP16 promoter was dramatically reduced by the transfection of si-p65 (Fig. 8E), suggesting that FGF18 could suppress the USP16 expression via p65."
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"Mechanistically, FGF18 treatment dramatically reduced the mRNA and protein levels of USP16, leading to reduction of the downregulation deubiquitination level of KEAP1 and the activation of Nrf2."
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"Mechanistically, FGF18 decreased expression of USP16 and thereby upregulated the KEAP1 ubiquitination level, leading to activation of the Nrf2 signaling pathway."
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