IndraLab

Statements

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"Ubiquitin-specific peptidase 47 also helps to promote EMT in normal cells (Silvestrini et al., 2020)."
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"To test the hypothesis that SATB1 is responsible for the USP47-induced EMT in colon cancer cells, we generated USP47-knockout HCT116 cells and overexpressed SATB1 in this cell line."
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of E-cadherin and promoted EMT through deubiquitination of Snail."
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"Silencing of USP47 accelerated the proteasomal degradation of Snail and inhibited EMT."
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
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"However, the relationship between EMT mediated by USP47 and E-cadherin was not explored in this study."
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"USP47 is an ubiquitin peptidase involved in hypoxia-induced EMT by SNAI1 deubiquitination and stabilization [187]."
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"Hypoxia-mediated induction of USP47 promotes EMT in colorectal cancer by transcriptional regulation of SNAIL expression [272]."
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"Here we report that upregulation of USP47 under hypoxic conditions stimulates EMT in CRC cells and subsequently their metastatic potential."
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"There were growing evidences supporting that USP47 promotes tumorigenesis, malignancies cell proliferation, drug resistance and epithelial-mesenchymal transition ( Hou et al., 2021 ; Park et al., 2022[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we identify Snai1 as a deubiquitination target of USP47, explaining USP47-dependent activation of the epithelial-mesenchymal transition pathway and tumor progression."
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"These results suggested that USP47 could mediate EMT by stabilizing SATB1 (Yu et al., 2019)."
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"USP47 subsequently stabilizes Snail by deubiquitination and promotes EMT and tumor metastasis (35)."
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"For example, USP47 stimulates TGF-β-induced EMT in mammary epithelial cells [98] ."
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of CDH1 and promoted EMT through deubiquitination of SNAIL [ 21 ]."
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"Because hypoxia induced USP47 expression enhanced EMT by stabilizing Snail, we investigated the contribution of USP47 to tumor growth and invasion in vivo."
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"As a regulator of Snail, USP47 enhances its expression under hypoxic conditions to induce epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC) cells [ 8 ]."
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"By utilizing the microarray database system of the Cancer Genome Atlas, we identified ubiquitin specific protease 47 (USP47), a deubiquitinating enzyme, as a potential mediator of hypoxia induced EMT."
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