IndraLab

Statements

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"Ubiquitin-specific peptidase 47 also helps to promote EMT in normal cells (Silvestrini et al., 2020)."
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"These results suggested that USP47 could mediate EMT by stabilizing SATB1 (Yu et al., 2019)."
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"Because hypoxia induced USP47 expression enhanced EMT by stabilizing Snail, we investigated the contribution of USP47 to tumor growth and invasion in vivo."
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"Additionally, chemical inhibition of USP47 reduced the expressions of several EMT markers, including CDH1, CTNNB1, and SNAIL, and reversed the morphological changes in MCF-10A cells undergoing EMT (Silvestrini et al., 2020)."
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"Here we report that upregulation of USP47 under hypoxic conditions stimulates EMT in CRC cells and subsequently their metastatic potential."
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"However, the relationship between EMT mediated by USP47 and E-cadherin was not explored in this study."
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"Silencing of USP47 accelerated the proteasomal degradation of Snail and inhibited EMT."
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"By utilizing the microarray database system of the Cancer Genome Atlas, we identified ubiquitin specific protease 47 (USP47), a deubiquitinating enzyme, as a potential mediator of hypoxia induced EMT."
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"The enhancement of USP47 in colorectal cancer cells under hypoxic conditions induced the disassembly of E-cadherin and promoted EMT through deubiquitination of Snail."
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