IndraLab

Statements

USP7 inhibits Wnt. 12 / 12
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"Genetic and pharmacological inhibition of USP7 enhances Wnt/β-catenin signaling and modulates Wnt-dependent osteoblast differentiation and adipocyte differentiation.Axin is a key scaffolding protein of the β-catenin destruction of complex, and cellular response to Wnt is extremely sensitive to the concentration of Axin ."
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"It has been shown previously that USP7 inhibition can induce apoptosis in various cancer cells via restoration of PTEN nuclear pool (Carrà et al., 2017), inhibition of Wnt signaling (An et al., 2017), and induction of oxidative and endoplasmic reticulum stress (Lee et al., 2016)."
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"Since USP7 negatively regulates Wnt signaling, we studied the function of USP7 in osteoblast differentiation in mouse multipotent mesenchymal stem cells C3H10T1/2 and mouse bone marrow-derived stroma cells ST2."
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"USP7 inhibits Wnt/beta-catenin signaling through promoting stabilization of Axin."
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"We confirmed that targeting USP7 can suppress tumor growth invivo by inhibiting Wnt activation."
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"On the other hand, incomplete KO of USP7 was sufficient to inhibit Wnt signaling and suppress tumor growth."
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"USP7 promotes adipocyte differentiation through repressing Wnt signaling."
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"Wnt-induced Axin ubiquitination is prolonged in USP7 knockout cells (Fig. 3j), suggesting that USP7 functions as a mechanism to limit Wnt-induced degradation of Axin."
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"The results showed that USP7 mediated Wnt activation in CRC is a reversible process."
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"Experimental results showed that USP7 overexpression suppressed the expression of several pathway-related genes, including Wnt, promoting cellular EMT and inhibiting cellular senescence and differentiation (128–130)."
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"Taken together, these results suggest that USP7 inhibits Wnt signaling through counteracting RNF146 and SIAH1-induced ubiquitination and degradation of Axin."
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"USP7 represses Wnt and beta-catenin signaling through stabilization of Axin, which is a part of the destruction complex that inhibits beta-catenin."
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