IndraLab

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"Flow cytometry was applied to detect changes in apoptosis of RPMI8226 and DOX cells (stained with annexin-V and propidium iodide) caused by inhibition by hydroxychloroquine and 3-methyladenine on autophagy."
26125760
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"Therefore, promoting senescence and impairing the autophagy-lysosomal pathway may be an important mechanism by which HCQ increases apoptosis and suppresses proliferation in PTECs when AKI is complicated by LN."
| PMC
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"Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition."
34568426
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"Similarly, HCQ induced apoptosis of cholangiocarcinoma cells with an up-regulation of ROS from our data."
34568426
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"Second, our results indicate that chloroquine and hydroxychloroquine abrogate CXCL12 mediated anti-apoptosis (XREF_FIG), wherein pretreatment with chloroquine or hydroxychloroquine increased apoptosis in PANC-1 cells."
22319600
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"HCQ inhibited cell proliferation and induced apoptosis and cycle arrest in vitro by increasing ROS accumulation, which was involved in autophagy inhibition."
34568426
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"Taken together, HCQ increases the apoptosis of rheumatoid synoviocytes by activating caspase-3, and also sensitizes rheumatoid synoviocytes to Fas mediated apoptosis."
16734620
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"CQ and HCQ can activate caspase-3 and modulate the Bcl-2 and Bax ratio inducing apoptosis in CLL, B-cell CLL and glioblastoma cells [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
29225688
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"HCQ was reported to induce skin fibroblast apoptosis at lower concentrations (10-20muM) 7, and Chol-HCQ showed lower toxicity than HCQ."
28878315
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"CQ and HCQ, well-known lysosomotropic agents, induce apoptosis, downregulate autophagy, and modify the tumour microenvironment."
35598250
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"It might therefore impact on innate immunity-induced immune hyperactivation.A recent study showed that hydroxychloroquine selectively induces apoptosis in the memory T-cell compartment (CD45RA− CD45RO+) [45]."
26084487
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"CQ and HCQ , well-known lysosomotropic agents , induce apoptosis , downregulate autophagy , and modify the tumour microenvironment ."
35598250
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"Mitochondrial membrane permeabilization is a critical step of lysosome initiated apoptosis induced by hydroxychloroquine."
12813466
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"They also concluded that HCQ causes mitochondrial membrane permeabilization and apoptosis."
31556748
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"We then noticed that HCQ alone could induce cancer cell apoptosis at a relatively higher concentration (> 40 μM) than that used in the combination treatment."
34844627
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"HCQ Induced Apoptosis in Cholangiocarcinoma Cells."
34568426
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"Furthermore, HCQ can induce apoptosis of SGC-7901 cells by inhibiting autophagy, which is the opposite of Rap."
27974905
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"Application of the autophagy inhibitor, hydroxychloroquine (HCQ) (10 microM), promoted apoptosis of primary HCC cells under hypoxic cultivation and 5-FU treatment, as evidenced by the increased expression of cleaved caspase-3 and cleaved caspase-8 (XREF_FIG) and inhibition of proliferation, as measured via MTT assays (XREF_FIG)."
33680119
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"Hence, CRC may be a potential therapeutic antioxidant for TRPM2 activation and HCQ treatment-induced retinal oxidative injury and apoptosis."
37099129
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"As shown in the Fig. S2F , HCQ could induce more obvious apoptosis in the siPIK3CA group ."
34844627
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"CQ and HCQ were shown to induce apoptosis and inhibit ATLL cell growth both in vitro and in vivo."
| PMC
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"These effects were blocked by bafilomycin A1, which prevents degradation of LC3, induces its accumulation in autophagolysosomes [66] and acts as an inhibitor of the vacuolar-type H+-ATPase, changing endosomal pH [67], showing that hydroxychloroquine activated apoptosis via lysosomes instead of other organelles (mitochondria or nuclei, for example)."
34527050
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"HCQ effectively promotes Bcl-xL inhibition-induced apoptosis in BxPC-3 human pancreatic cancer cells."
35790256
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"Hydroxychloroquine induced apoptosis in human lymphocytes from normal subjects and synoviocytes taken from RA patients [ 209 , 210 ] ."
| PMC
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"Western blotting analysis subjected that HCQ can induce apoptosis of SGC-7901 cells by inhibiting autophagy, which is the opposite of Rap (XREF_FIG)."
27974905
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"Hydroxychloroquine can potentially increase apoptosis in FLS through its effects on the pro-apoptotic enzyme caspase-3 and enhances apoptosis mediated by CD95[29]."
36228471
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"The present study demonstrated that HCQ induces apoptosis in peripheral blood lymphocytes, which leads to the speculation that HCQ may exert its antirheumatic effect through this mechanism."
9153556
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"The aim of this study was to investigate whether hydroxychloroquine (HCQ) blocks autophagy and promotes apoptosis of the prostate after castration."
32937616
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"In addition, we found that hydroxychloroquine (HCQ)- or si-ATG5-induced autophagy inhibition further demoted bee venom-induced apoptosis."
36590307
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"Additionally, HCQ induces apoptosis of autoreactive T-cells and interferes with antigen processing by B-cells, thereby interfering with their functions and cytokine production (interleukin [IL]-1, IL-6, interferon-gamma, tumour necrosis factor [TNF], and B-cell activating factor) [XREF_BIBR, XREF_BIBR]."
33095083
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"CONCLUSIONS: Our study revealed that HCQ and BKM120 synergistically increased DSBs in tumor cells and therefore augmented apoptosis, resulting in enhanced antitumor efficacy."
34844627
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"In an in vitro model, results showed that HCQ promoted apoptosis of macrophages and inhibited activation of macrophages, especially M2 macrophages, in a dose dependent manner."
33936063
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"Hydroxychloroquine induced apoptosis of chronic lymphocytic leukemia involves activation of caspase-3 and modulation of Bcl-2/bax/ratio."
12148891
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"HCQ triggers apoptosis and suppresses cell proliferation."
26134285
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"Since there is evidence that HCQ has a potential application in cancer treatment for its inhibition of autophagy in leukemic, breast cancer MCF-7 and melanoma cells and may subsequently induce their apoptosis, this process may also be important to the actions of HCQ in cervical cancer cells."
24944668
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"HCQ can induce apoptosis of cholangiocarcinoma and ROS accumulation."
34568426
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"HCQ enhances the effect of temsirolimus on cytotoxicity and promotes apoptosis in renal cell carcinoma lines."
33367926
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"Baf was shown to prevent accumulation of the phospholipogenic compound hydroxychloroquine in Hela cells and reduced apoptosis caused by hydroxychloroquine treatment [XREF_BIBR]."
23577025
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"The hypothesis that CQ might afford Ebola prophylaxis comes from our own work showing hydroxychloroquine (HCQ) induces apoptosis (programmed cell death) in peripheral blood mononuclear cells.2 HCQ also inhibits the replication of HIV in vitro.3There is a possible clinical analogy."
26135157
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"HCQ inhibited cell proliferation and induced apoptosis and cycle arrest in vitro by increasing ROS accumulation , which was involved in autophagy inhibition ."
34568426
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"Recently, it has been shown that caspase-independent disruption of the mitochondrial membrane regulated by the Bcl-2 family proteins is the rate-limiting step for apoptosis induced by hydroxychloroquine [4] ."
14975502
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"In addition, HCQ activated ATM to enhance HR repair, a high-fidelity repair for DNA double-strand breaks (DSBs) in cells, while BKM120 inhibited HR repair by blocking the phosphorylation of ATM and the expression of BRCA1/2 and Rad51.Our study revealed that HCQ and BKM120 synergistically increased DSBs in tumor cells and therefore augmented apoptosis, resulting in enhanced antitumor efficacy."
34844627
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"ese effects were blocked by bafilomycin A1, which prevents degradation of LC3, induces its accumulation in autophagolysosomes [66] and acts as an inhibitor of the vacuolar-type H + -ATPase, changing endosomal pH [67] , showing that hydroxychloroquine activated apoptosis via lysosomes instead of other organelles (mitochondria or nuclei, for example)."
34527050
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"Here, we report that HCQ combined with 2-DG can further inhibit the viability and migration and induce apoptosis of breast tumour cells compared with other individual drugs."
35690609
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"Chloroquine and Hydroxychloroquine Trigger Apoptosis and Inhibit CXCL12 Mediated Proliferation and Anti-Apoptosis."
22319600
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"Hydroxychloroquine can potentially increase apoptosis in FLS through its effects on the pro-apoptotic enzyme caspase-3 and enhances apoptosis mediated by CD95 [ 29 ] ."
36228471
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"Moreover, both CQ and HCQ induced significant apoptosis of HEK293 in normoxia and hypoxia (XREF_FIG)."
33658924
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"It might therefore impact on innate immunity-induced immune hyperactivation.A recent study showed that hydroxychloroquine selectively induces apoptosis in the memory T-cell compartment ( CD45RA - CD45RO + ) [ 45 ] ."
26084487
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"RAPA and HCQ inhibited the proliferation of RPMI8226 in a concentration- and time dependent manner, and increased the apoptosis."
29950226
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"HCQ alone induced apoptosis in a concentration-dependent manner , with an increase in cleaved PARP ( Fig. S4C-E ) ."
34844627
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"The combination of HCQ with BKM120 synergistically induced the accumulation of ROS and caspase-dependent apoptosis."
34844627
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"HCQ was able to induce apoptosis in peripheral blood lymphocytes in a dose- and time dependent manner."
9153556
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"Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition ."
34568426
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"The ROS scavenger reduced l-glutathione distinctly weakened HCQ-induced cell apoptosis and viability inhibition in cholangiocarcinoma cells."
34568426
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"Conclusion : HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition , which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment ."
34568426
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"Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy : A possible mechanism for therapeutic modulation of T cells."
23541328
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"As shown in Fig. 3a , HCQ reduced viral infection by blocking autophagy activation induced by PEDV in a dose-dependent manner ; it seems that HCQ improved apoptosis via depressing autophagy ."
| PMC
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"Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms."
35705919
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"However, HCQ may promote SiHa cell apoptosis as the MTT, apoptotic assay and miRNA-9 * results revealed."
24944668
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"HCQ alone induced apoptosis in a concentration-dependent manner, with an increase in cleaved PARP (Fig. S4C-E)."
34844627
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"Hydroxychloroquine Promotes Bcl-xL Inhibition-induced Apoptosis in BxPC-3 Human Pancreatic Cancer Cells."
35790256
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"Consistent with the FCM results, the Live/Dead cell assay revealed a significant transition from the calcein signal to the PI signal (Figure 3B), indicating that HCQ-induced apoptosis increased with the increase of dose."
34568426
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"Hydroxychloroquine was also shown to induce apoptosis of malignant B-cells from patients with chronic lymphocytic leukemia (CLL), through the activation of caspase-3 and modulation of Bcl-2/bax ratio [69, 70]."
21221847
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"In contrast, apoptosis induced by hydroxychloroquine (HCQ) in HL-60 cells was caspase-3 independent and was fully inhibited by ATA."
11227493
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"The combination of hydroxychloroquine and 2-deoxyglucose enhances apoptosis in breast cancer cells by blocking protective autophagy and sustaining endoplasmic reticulum stress."
35690609
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"They also concluded that HCQ causes mitochondrial membrane permeabilization and apoptosis ."
31556748
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"This is based on the experiments with bafilomycin A 1 / hydroxychloroquine, in which we showed that autophagy prevented cells from undergoing DOC induced apoptosis, but not from DOC induced necrosis."
20130808
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"A combined treatment of HCQ and anti-Fas mAb increased FLS apoptosis and caspase-3 activity synergistically, compared with either anti-Fas mAb or HCQ alone."
16734620
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"HCQ promotes T-cell apoptosis and inhibits B-cell antigen processing , thereby decreasing T-cell - and B-cell-mediated cytokine release ."
33095083
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"And both CQ and HCQ could induce cell cycle arrest and apoptosis which are consistent with the phenotype of proliferation and could partially explain the toxic effect of CQ and HCQ ( Supplementary Figures 3A , B ) ."
33658924
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"A recent study showed that hydroxychloroquine selectively induces apoptosis in the memory T-cell compartment ( CD45RA - CD45RO + ) [ 45 ] ."
26084487
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"Autophagy increased after castrated in prostates, while decreased after treated with HCQ; all these indicated that HCQ blocked autophagy and then promoted prostate apoptosis of castrated mice."
32937616
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"Hydroxychloroquine Blocks Autophagy and Promotes Apoptosis of the Prostate after Castration in Rats."
32937616
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"HCQ administration promoted PTEC apoptosis and arrested cell cycle progression at G1/S phase in LN."
| PMC
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"Hydroxychloroquine Potentiates Apoptosis Induced by PPARalpha Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy."
33959154
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"Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
34568426
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"Likewise, hydroxychloroquine potentiates Fas‐mediated apoptosis of synoviocytes (65)."
17970883
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"HCQ alone produced decreased cell growth and induction of caspase-dependent apoptosis in all S45F mutated DT cells tested but had no effect in T41A-mutated DT cells, confirming our previous results that S45F-mutated DT cell strains are highly dependent on autophagy instead of apoptosis."
30980399
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"Moreover, HCQ inhibits T cell activation, proliferation, and cytokine production by inhibiting intracellular calcium and mobilization and subsequent NFAT signalling [XREF_BIBR, XREF_BIBR] and apoptosis in CD45RO+ memory and effector T cells by inhibiting autophagy [XREF_BIBR]."
33763494
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"These results indicated that HCQ inhibited autophagy in all patients ' tumors but caused apoptosis only in the tumors of patients who showed elevated Par-4 secretion in their plasma in response to HCQ ."
30603055
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"As shown in the Fig. S2F, HCQ could induce more obvious apoptosis in the siPIK3CA group."
34844627
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"We here demonstrate that hydroxychloroquine preferentially induces apoptosis of CD45RO+ memory and effector T cells by inhibiting the survival pathway of autophagy."
23541328
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"Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line."
37099129
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"Mouse embryonic fibroblasts lacking the expression of both Bax and Bak are resistant against hydroxychloroquine induced apoptosis."
12813466
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"Anti–PD-1 Ab and HCQ produced significantly increased apoptosis in tumor tissue (Figure 1D) and increased the survival of mice compared with anti–PD-1 Ab alone (Figure 1E)."
32780726
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"CQ and HCQ treatment leads to bladder cancer cell apoptosis [42] and growth suppression through the downregulation of matrix metalloproteinase-2 (MMP-2) by inhibiting autophagy [43]."
35381976
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"Our study revealed that HCQ and BKM120 synergistically increased DSBs in tumor cells and therefore augmented apoptosis, resulting in enhanced antitumor efficacy."
34844627