IndraLab

Statements

DEAF1 binds KCNMA1. 9 / 9
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"It remains to be determined whether similar mechanisms are responsible for the interactions between SLO, SPN and the host cell membrane."
25196983
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"In summary, our mouse virulence data confirmed the functional association between SPN and SLO."
28034602
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"These results confirmed the intimate functional association between SPN and SLO."
28034602
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"SPN was not detected at cell membranes when secreted with mutants of SLO that are restricted to cholesterol dependent membrane binding, leading to the hypothesis that a co-dependent interaction between SPN and SLO at the host cell surface is necessary for SLO 's cholesterol-insensitive mode of binding."
25196983
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"The fact that SLO always interacts with cells in combination with SPN may help to explain that despite extensive analysis, SLO 's function in infection remains poorly understood (for review, see)."
25818652
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"Surprisingly, this cholesterol-insensitive binding requires the co-expression and membrane localization of SPN, suggesting that CMT may be a cholesterol-insensitive process that occurs following an interaction between SPN and SLO at the host cell membrane."
25196983
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"Surprisingly, the lytic activity of the SLO variants requires the co-expression of SPN, indicating that in the absence of glycan binding by SLO, the SPN dependent interaction of SLO at the host cell membrane is sufficient for pore formation during infection."
26059530
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"It is possible that the interaction of SPN and SLO at the membrane contributes to perturbations leading to inhibition of pore healing that may occur in the absence of SPN."
26838722
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"Since SLO membrane binding is necessary for the translocation of SPN into host cells, it seemed likely that SPN and SLO co-associate at the host cell surface prior to the translocation of SPN."
25196983