IndraLab

Statements

TP53 activates mutated TP53. 17 / 17
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"Sirt1 may inactivate the 382nd lysine residue of p53, reduce the expression of the wild-type p53 protein combining with the DNA cis element to promote p53 mutation."
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"Thus, these data indicate that GCS suppression restores wild-type p53 expression and leads mutant p53 tumors to induced-apoptosis."
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"Genotoxic stressors cause strong promoter activation and upregulation of p53 transcription, which could increase p53 mutation frequencies."
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"We found that JNK mediated phosphorylation of Thr 81 in the proline rich domain (PRD) of p53 enabled wild-type p53, as well as mutant p53, to form a complex with p73."
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"In the absence of stress, p53 is stochastically expressed, activating nuclear Akt in an on/off mode, whereas mutant p53 is highly expressed and activates nuclear Akt constitutively, reflecting the hyperstability of mutant p53 relative to p53 ."
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"The constitutive overexpression of p53 overcame endogenous negative regulation in D283 cells, and rescued TP53 mutation in VP-16-treated Daoy cells."
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"It is noteworthy that in all of these cancers, heterogeneity of TP53 expression could be observed, raising the possibility of focal TP53 mutations in a tumour subclone that may not have been detected by the sequencing assays."
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"Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line."
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"As coexpression of wild-type p53 protein was shown to promote destabilization of the mutant p53 protein [15], the above difference supports the idea that the tumors retaining heterozygosity at the sit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ESR1 mutant tumors do not exhibit differential p53 pathway activity, whereas we identified attenuated ER activity and expression in TP53 mutant tumors, driven by a p53-associated E2 response gene signature."
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"Delta122p53, a mouse model of Delta133p53alpha, enhances the tumor-suppressor activities of an attenuated p53 mutant."
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"On the other hand, overexpressed RPS27 may in turn stabilize mutant p53, since ectopic expression of RPS27 could increase p53 levels (XREF_FIG)."
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"XREF_BIBR The targeting of mutant TP53 epitopes or TP53 overexpression in tumors by vaccine has shown promise in a number of in vivo settings."
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"19 In this paper, we report that Delta122p53 enhanced the tumor-suppressor activities of the attenuated p53 mutant mDeltapro."
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"This statement could be supported by previous studies showing that S15 phosphorylation of TP53 contributed mutant TP53 stability, thereby prolonging cell viability in ovarian cancer cells, and S392 phosphorylation in mutant TP53 could lead to tumor progression in esophageal squamous cell carcinoma."
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"Of note, in all of these cases, heterogeneity of p53 expression could be observed, raising the possibility of focal TP53 mutations in a tumor subclone that may not have been detected by the sequencing assays (XREF_FIG)."
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"The p53 levels in cyclin D1-HA and FHL2 -/- cells were as high as those in wt MEFs in the absence of treatment, and did not increase in response to doxo, reflecting mutant p53 (XREF_FIG), and similar results were obtained with two independent cyclin D1-HA and FHL2 -/- cell pools (data not shown)."
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