IndraLab

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USP9X leads to the deubiquitination of RICTOR. 2 / 2

1 | 1

"<span class="match term0">USP9X</span> removes Lys63-linked ubiquitin from <span class="match term1">RICTOR</span> to promote its interaction with mTOR, thereby facilitating mTORC2 signaling"

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"Conversely, overexpression of USP9X in HEK293 cells decreased RICTOR ubiquitination ( Figure 3 D); increased phosphorylation of AKT at Ser473, without affecting phosphorylation of AKT-Thr308 or S6K ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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INDRA sources:

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IndraLab

Statements

USP9X leads to the deubiquitination of RICTOR. 2 / 2

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