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Crizotinib inhibits KCNH2. 3 / 4
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"Doherty and colleagues have reported that crizotinib suppressed hERG channels and caused cardiotoxicity by increasing ROS production, cholesterol accumulation, and activating the apoptotic cascade in cardiomyocytes in vitro [59]."
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"For example, crizotinib that has been approved for the NSCLC treatment, inhibits Kv11.1 the ion channel responsible for the delayed-rectifier potassium current in the heart."
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"QTc prolongation has been observed in patients receiving crizotinib (Xalkori, 2011) and the clinical review (Pfizer I, 2011a) reported that crizotinib inhibits hERG at concentrations consistent with t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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