IndraLab

Statements

Geldanamycin inhibits RIPK1. 4 / 4
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"Compared with etanercept, a TNF-α inhibitor, geldanamycin inhibits the RIPK1 and NF-KB activity while augmenting the activation of caspase-8 to promote MH7A cell apoptosis, and inhibit TNF-α-induced necroptosis."
35003139
eidos
"Compared with etanercept , a TNF-alpha inhibitor , geldanamycin inhibits the RIPK1 and NF-KB activity while augmenting the activation of caspase-8 to promote MH7A cell apoptosis , and inhibit TNF-alpha-induced necroptosis ."
35003139
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"Geldanamycin disrupted RIPK1 in MH7A, thereby inhibiting TNFalpha induced proinflammatory cytokine production and enhancing apoptosis."
33415454
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"Key Points * Geldanamycin (GM) disrupts RIPK1 and selectively inhibits the TNFR1 triggered NF-kappaB activation signaling pathway while enhancing the apoptosis signaling pathway upon TNFalpha stimulation, thereby redressing the balance between these two opposing signals in a human rheumatoid synovial cell line, MH7A."
33415454