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Statements

USP22 inhibits Mice. 3 / 3
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"Indeed, USP22 was recently shown to be involved in the early development of mouse embryos, with USP22 deletion causing embryonic lethality and mice carrying a hypomorphic USP22 allele displaying viabi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Accordingly, USP22 downregulation also attenuated cerebral I/R-induced oxidative stress, inflammation, and cell apoptosis in mice, thereby reducing nerve injury and neurological dysfunction [20]."
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"However, deletion of Usp22 significantly decreased tumor burden and increased survival of MMTV-NIC mice."
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